2026 NFL Odds Week 2: Lines, Spreads, Results For All 16 Games

Week 2 is in our sights, headlined by a Thursday night clash between the Lions and the Bills in Buffalo.

Here are the lines for every Week 2 matchup at bet365 Sportsbook as of Sept. 14. 

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Lions @ Bills

Spread: Bills -3.5
Moneyline: Bills -185, Lions +155
O/U: 53.5

Panthers @ Falcons

Spread: Falcons -1.5
Moneyline: Falcons -120, Panthers +100
O/U: 44.5

Bengals @ Texans

Spread: Texans -2.5
Moneyline: Texans -140, Bengals +120
O/U: 47.5

Browns @ Buccaneers

Spread: Bucs -8.5
Moneyline: Bucs -425, Browns +325
O/U: 40.5

Packers @ Jets

Spread: Packers -4.5
Moneyline: Packers -220, Jets +180
O/U: 45.5

Vikings @ Bears

Spread: Bears -5.5
Moneyline: Bears -250, Vikings +205
O/U: 48.5

Saints @ Ravens

Spread: Ravens -8.5
Moneyline: Ravens -425, Saints +325
O/U: 47.5

Eagles @ Titans 

Spread: Eagles -7
Moneyline: Eagles -340, Titans +270
O/U: 39.5

Steelers @ Patriots

Spread: Patriots -5.5
Moneyline: Patriots -240, Steelers +195
O/U: 42.5

Jaguars @ Broncos

Spread: Broncos -2.5
Moneyline: Broncos -140, Jaguars +120
O/U: 43.5

Raiders @ Chargers

Spread: Chargers -7.5
Moneyline: Chargers -330, Raiders +265
O/U: 44.5

Dolphins @ 49ers

Spread: 49ers -12.5
Moneyline: 49ers -950, Dolphins +625
O/U: 46.5

Commanders @ Cowboys

Spread: TBD
Moneyline: TBD
O/U: TBD

Seahawks @ Cardinals 

Spread: Seahawks -4.5
Moneyline: Seahawks -230, Cardinals +190
O/U: 41.5

Colts @ Chiefs

Spread: Chiefs -6.5
Moneyline: Chiefs -290, Colts +235
O/U: 48.5

Giants @ Rams

Spread: TBD
Moneyline: TBD
O/U: TBD

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